A Combination of Phyllanthus niruri, Chrysanthellum Americanum, Potassium and Magnesium Citrate Reduces the Risk of Recurrent Urinary Stones

Written by Taylor Woosley, Staff Writer. 6-month treatment of a food supplement containing Phyllanthus niruri, Chrysanthellum Americanum, potassium citrate and magnesium citrate significantly improved QoL scores (p < 0.001) and reduced average stone size in comparison with the baseline (p<0.001).  (more…)

Six Non-Essential Amino Acids Improves Joint Pain and Stiffness in Healthy Subjects with Joint Discomfort

Written by Taylor Woosley, Staff Writer. 12-week supplementation of 12 g of 6 non-essential amino acids (alanine, aspartic acid, glutamic acid, glycine, proline, and serine) resulted in improved VAS, JKOM, and JOA scores, suggesting that the treatment group experienced improved joint pain, discomfort, and stiffness both in a resting state and during normal activity.  (more…)

Resveratrol May Significantly Improve Serum Levels of Total Cholesterol, Triglycerides and Low-Density Lipoprotein Cholesterol

Written by Taylor Woosley, Staff Writer. Results of the dose-response meta-analysis including 17 RCTs show that resveratrol supplementation significantly decreased TC (p < 0.001), TG (p < 0.001), and LDL-C (p=0.038). Furthermore, results from the sub-group analysis show that a more significant reduction of LDL-C was observed in trials with a duration of 12 weeks.  (more…)

Water-Soluble Tomato Concentrate Inhibits Platelet Activation and Aggregation in Healthy Middle-Aged and Elderly Subjects

Written by Taylor Woosley, Staff Writer. Results of the 10-week randomized, double-blinded, placebo-controlled crossover trial show that WSTC increased the serum total antioxidant capacity levels (p<0.05), while attenuating platelet endogenous reactive oxygen species generation (p<0.05), and inhibiting platelet aggregation and activation (p<0.05).  (more…)

Pycnogenol® Relieves Symptoms Related to Restless Leg Syndrome & Improves the Venoarteriolar Response

Written by Taylor Woosley, Staff Writer. 4-week supplementation of 150 mg/day of Pycnogenol significantly improved Visual Analogue Scale Line scores (P<0.05) and significantly decreased levels of oxidative stress (P<0.05). Furthermore, subjects in the Pycnogenol® group had a significant (>15%) increase in venoarteriolar response.  (more…)

Higher Potassium Intake Associated with Lower Risk of Cardiovascular Disease

Written by Taylor Woosley, Staff Writer. Both men and women within the highest tertile of potassium intake had a lower risk of CVD events compared with those within the lowest tertile of potassium intake, but the HR associated with high potassium intake was lower in women than in men (fully adjusted model: men: HR 0.93, 95% CI 0.87–1.00; women: HR 0.89, 95% CI 0.83–0.95).  (more…)

Vitamin D Supplementation Reduces Depressive Symptoms in Subjects with Major Depressive Disorder

Written by Taylor Woosley, Staff Writer. Significant findings of this systemic review and meta-analysis of 41 papers with a total of 53,235 participants show that subgroup analysis in participants with clinically relevant depressive symptoms (including subjects with MDD) yielded a moderate effect favoring vitamin D supplementation (Hedges’ g = −0.604, 95% CI −0.802 to −0.406, p < 0.001, I2 = 78.4%).  (more…)

Fermented Blackberry (BB-1000) Supplementation Significantly Reduces Eye Wrinkles in Subjects

Written by Taylor Woosley, Staff Writer. 12-week supplementation with BB-1000 (blackberry fermented by Lactobacillus plantarum JBMI F5) at 800 mg/day reduced the degree of eye wrinkles to 0.22 ± 0.47 from baseline at 12 weeks. Furthermore, the skin wrinkle volumes of the BB-1000 group increased by 2.65 ± 1.94 mm3 at 12-weeks, compared to placebo (p < 0.05).  (more…)

Vitamin D3 Repletion Improves Vascular Function and Reduces Full Length Osteopontin in Vitamin D Deficient African American Subjects

Written by Taylor Woosley, Staff Writer. Monthly supplementation of 100,000 IU of cholecalciferol was associated with a 2-fold increase in vitamin D levels, from 17 ± 5 ng/mL to 35 ± 7 ng/mL (p < 0.0001) after 12 weeks. Serum levels of log transformed flOPN were significantly reduced (p=0.03) and log FGF-23 was increased in the treated group (p = 0.04). (more…)

Selenium Supplementation Improves Glutathione Peroxidase Activity in Alzheimer’s Patients

Written by Taylor Woosley, Staff Writer. Analysis of a systemic review of 11 studies and a meta-analysis including 6 papers show that selenium supplementation increased MDA levels significantly by an average of 0.95 (0.44, 1.45) times (p = 0.0002). Furthermore, Se only supplementation significantly increased GPX activity by an average of 0.95 (0.59, 1.31) times (p = 0.00001).  (more…)