Written by Taylor Woosley, Staff Writer. Serum levels of ALT (p < 0.001), bilirubin (p < 0.001), IgG (p = 0.008), and INR (p = 0.005) were significantly higher in patients with PSC and a severe vitamin D deficiency when compared to their counterparts. (more…)
Written by Taylor Woosley, Staff Writer. Centenarians with three risk factors (low serum 25(OH)D and higher PTH and β-CTX levels) and those with two risk factors had, respectively, had a 2.02-fold and 1.49-fold increase in risk of all-cause mortality in comparison with centenarians with no risk factors. (more…)
Written by Jessica Patella, ND. The study found an association between regular vitamin D supplement takers and lower percentages of past or present melanoma compared to non-supplementers (32/117, 18.1% vs. 32/99, 32.3%, p=0.021). (more…)
Written by Taylor Woosley, Staff Writer. Analyzing data from 4570 patients with osteoarthritis shows that subjects with sufficient serum 25(OH)D were associated with a decreased risk of all-cause mortality and CVD mortality compared with those with lower 25(OH)D levels. (more…)
Written by Taylor Woosley, Staff Writer. Results of this prospective cohort study using data from the 2001-2006 NHANES shows that each 1-unit increase in serum 25(OH)D concentration was related to a 41% lower risk of all-cause mortality and a 65% lower risk of cardiovascular mortality in the fully adjusted model. (more…)
Written by Taylor Woosley, Staff Writer. A single high dose of vitamin D3 (80,000 IU) increased subject’s vitamin D status by approximately 60% and significantly reduced the serum levels of proinflammatory cytokines IL-6, IL-8 and TNF-α. (more…)
Written by Taylor Woosley, Staff Writer. A 1-µg/day increase in dietary vitamin D intake was associated with a beneficial 5-year change in pain severity, pain frequency, and number of pain locations. (more…)
Written by Taylor Woosley, Staff Writer. Study analysis of 294970 subjects who participated in the UK Biobank shows that compared with those with 50 nmol/L, individuals with serum 25(OH)D concentration at 25 nmol/L have a 6.4% (95% CI, 3.85-8.98) higher serum CRP concentration. (more…)
Written by Taylor Woosley, Staff Writer. Significant findings of this systemic review and meta-analysis of 41 papers with a total of 53,235 participants show that subgroup analysis in participants with clinically relevant depressive symptoms (including subjects with MDD) yielded a moderate effect favoring vitamin D supplementation (Hedges’ g = −0.604, 95% CI −0.802 to −0.406, p < 0.001, I2 = 78.4%). (more…)
Written by Taylor Woosley, Staff Writer. Monthly supplementation of 100,000 IU of cholecalciferol was associated with a 2-fold increase in vitamin D levels, from 17 ± 5 ng/mL to 35 ± 7 ng/mL (p < 0.0001) after 12 weeks. Serum levels of log transformed flOPN were significantly reduced (p=0.03) and log FGF-23 was increased in the treated group (p = 0.04). (more…)
Written by Taylor Woosley, Staff Writer. Evaluating data from 9 RCT studies assessing changes in fibromyalgia patient’s pain symptoms as a result of vitamin D supplementation show that supplementation may have beneficial effects for musculoskeletal pain in subjects with 25OHD deficiency. (more…)
Written by Taylor Woosley, Staff Writer. Nonlinear MR analyses show the threshold effect of 25(OH)D levels on dementia, with the risk predicted to be 54% (95% CI: 1.21, 1.96) higher for participants at 25 nmol/L compared with 50 nmol/L. (more…)
Written by Taylor Woosley, Staff Writer. Examining vitamin D serum levels and prevalence of insulin resistance using data from the 2011-2018 National Health and Nutrition Examination Survey show that those in the lowest serum vitamin D level group had 54% greater odds of being insulin-resistant compared to those in higher serum vitamin D level groups. (more…)
Written by Chrystal Moulton, Staff Writer. Deficient levels of serum 25(OH)D (<12ng/mL) is associated with increased risk of all-cause, cancer, and cardiovascular mortality in Korean adults. (more…)
Written by Taylor Woosley, Staff Writer. Results of the study show that deficient and insufficient levels of serum 25-OH-D are associated with higher depression scores. The odds of a higher depression score were significantly higher in participants with insufficient 25-(OH)-D than in participants with 25-OH-D sufficiency (OR = 6.40, p < 0.001). (more…)
Written by Jessica Patella, ND. Results from this study suggest 15-minutes of time outside and/or supplementing with vitamin D should be considered for the elderly in community-dwelling locations. (more…)
Written by Taylor Woosley, Staff Writer. Analysis of a prospective cohort study with data collected from around 267, 980 subjects, using Mendelian randomization framework, resulted in a non-linear association between 25(OH)D levels and CVD risk. Every 10 nmol/L increase in serum 25(OH)D levels was associated with 1.6% lower odds of CVD. (more…)
Written by Jessica Patella, ND. Study concluded that among patients hospitalized for COVID-19, pre-infection deficiency of vitamin D was associated with an increase in disease severity and mortality. (more…)
Written by Taylor Woosley, Staff Writer. A total of 41 randomized controlled trials observing the effects vitamin D supplementation may have on overall cholesterol levels were analyzed. Findings suggest vitamin D supplementation, especially in participants with deficient levels, improved serum total cholesterol levels, LDL cholesterol levels, and triglyceride levels. (more…)
Written by Taylor Woosley, Staff Writer. Study results show that infected participants with deficient levels of vitamin D and zinc experience higher severity of general and pulmonary symptoms of COVID-19 compared to participants with adequate vitamin D and zinc serum levels. (more…)
