Controversy over the Role of Natural Vitamin E in Reducing Leading Causes of Death. See presentations by Michael Lelah, PhD, Qing Jiang, PhD, Barrie Tan, PhD, Sridevi Devaraj, PhD, Chandan Sen, PhD, Neil Levin, CCN.
Natural vs. Synthetic Vitamin E
Written by Michael Lelah, Ph.D., Conference paper presented at the American Oil Chemists’ Society (AOCS) Hot Topics Symposium, May 2006. Theme: Controversy over the Role of Natural Vitamin E in Reducing Leading Causes of Death. Read more
Vitamin E – Hype or Science? – Informed Opinion
By Neil E. Levin, CCN, DANLA, Nutrition Education Manager. Conference paper presented at the American Oil Chemists’ Society (AOCS) Hot Topics Symposium. May 2006. Theme: Controversy over the Role of Natural Vitamin E in Reducing Leading Causes of Death. Posted July 2, 2008. Read more
Natural Forms of Vitamin E as Anti-inflammatory and Anti-cancer Agents
Conference paper presented at the American Oil Chemists’ Society (AOCS) Hot Topics Symposium. May 2006. Theme: Controversy over the Role of Natural Vitamin E in Reducing Leading Causes of Death.
Recent studies by us and others indicate that other forms of vitamin E, compared with TT, have distinct biological activities that may be important to public health. We have shown that i-tocopherol (-T) and its metabolite, but not TT, inhibit cyclooxygenase-catalyzed proinflammatory PGE2 formation in cell culture and in a rats’ inflammation model. We recently found that WT, in contrast to TT, inhibited growth and induced death in cancer cells by modulating sphingolipid intermediates. T-Tocotrienol appears to be even more potent than -T in anti-proliferation and pro-apoptosis effect. Both TT and T-tocotrienol reduced tumor growth in nude mice implanted with prostate cancer cells. These observations strongly suggested that non-alpha forms of vitamin E are important in disease prevention and therapy.
By Qing Jiang, Ph.D.
New Perspectives and Applications for Desmethyl Tocotrienols and Desmethyl Tocopherols
By Barrie Tan, Ph.D., Conference paper presented at the American Oil Chemists’ Society (AOCS) Hot Topics Symposium. May 2006. Theme: Controversy over the Role of Natural Vitamin E in Reducing Leading Causes of Death.
This presentation delineates the role of desmethyl tocopherols and desmethyl tocotrienols in biological studies and in human health. A new “appropriate spectrum” perspective –consistent with what has been published in the last decade — will be proposed for applications of delta-tocotrienol, gamma-tocotrienol, delta-tocopherol and gamma-tocopherol. An “appropriate spectrum” reflects a daily consumption (DC) of 35-40mg vitamin E, approximating to 17-20mg (50%) of gamma-tocopherol, 7-8mg (20%) of alpha-tocopherol, 7-8mg (20%) of beta- and delta-tocopherols, and 3-4mg (10%) of tocotrienols combined. Formulated “appropriate spectrum” vitamin E should more closely resemble the composition of our diet (e.g., 1xDC for maintenance, 10xDC for prevention) but disease treatment may require different doses (e.g., 50-200mg/day desmethyl tocotrienols).
New Perspectives and Applications for Desmethyl Tocotrienols and Desmethyl Tocopherols
By Barrie Tan, Ph.D., Conference paper presented at the American Oil Chemists’ Society (AOCS) Hot Topics Symposium. May 2006. Theme: Controversy over the Role of Natural Vitamin E in Reducing Leading Causes of Death.
This presentation delineates the role of desmethyl tocopherols and desmethyl tocotrienols in biological studies and in human health. A new “appropriate spectrum” perspective –consistent with what has been published in the last decade — will be proposed for applications of delta-tocotrienol, gamma-tocotrienol, delta-tocopherol and gamma-tocopherol. An “appropriate spectrum” reflects a daily consumption (DC) of 35-40mg vitamin E, approximating to 17-20mg (50%) of gamma-tocopherol, 7-8mg (20%) of alpha-tocopherol, 7-8mg (20%) of beta- and delta-tocopherols, and 3-4mg (10%) of tocotrienols combined. Formulated “appropriate spectrum” vitamin E should more closely resemble the composition of our diet (e.g., 1xDC for maintenance, 10xDC for prevention) but disease treatment may require different doses (e.g., 50-200mg/day desmethyl tocotrienols).
