Saffron Benefits for Eye Health, Neurodegeneration, and Mood Disorders

by | Mar 24, 2025 | Botanicals, Brain Health, Eye Health, Recent Articles

Written by Taylor Woosley, Science Writer. Research suggests that saffron could boost your health and emotional well-being. Its bioactive compounds have been shown to have a wide spectrum of biological activities, including exerting anti-inflammatory, hypotensive, hypoglycemic, antihyperlipidemic, antidegenerative and antidepressant properties, among others.

saffronSaffron, derived from the Crocus sativus L. flower, has long been celebrated for both its culinary and medicinal uses. It is renowned as one of the most expensive spices globally. Historically, saffron has been used for thousands of years in traditional medicine, with ancient civilizations such as the Egyptians, Persians, Greeks, and Romans valuing it for its healing properties and mood-enhancing effects.

The health benefits of saffron are largely attributed to its key bioactive compounds: crocin, safranal, and picrocrocin. These compounds have been shown to have a wide spectrum of biological activities, including exerting anti-inflammatory, hypotensive, hypoglycemic, antihyperlipidemic, antidegenerative and antidepressant properties, among others1.

In addition to these bioactive compounds, saffron boasts a rich nutritional profile, being a source of vitamins, minerals, and essential oils. This combination of nutrients extends saffron’s benefits beyond its therapeutic properties, playing a vital role in supporting overall health and emotional well-being.

Saffron’s Effects on Neurodegenerative Disorders

Neurodegenerative disorders are a group of debilitating conditions characterized by the progressive degeneration of the structure and function of the nervous system. Examples include Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. These disorders not only impair cognitive and motor functions but also significantly diminish the quality of life for both patients and caregivers.

The prevalence of neurodegenerative disorders is increasing, affecting millions of people worldwide. Recent studies predict a rise in the global burden of these diseases as the population ages, highlighting the urgency for effective strategies to support brain health and mitigate the impact of these disorders.

Saffron has been studied for its potential neuroprotective properties. Rich in antioxidants and bioactive compounds, saffron may support brain health by exerting anti-inflammatory and antioxidant effects such as inhibition of inflammatory associated cytokines and the reduction of oxidative stress and reactive oxygen species2.

Research suggests that saffron may reduce neurodegeneration by modulating various neurochemical pathways and reducing neuroinflammation3. For instance, its active components have been shown, in pre-clinical data, to promote neuronal survival, inhibit beta-amyloid aggregation and neurotoxicity, and prevent senile plaques and neurofibrillary tangle formation4. By protecting neurons from damage and promoting brain health, saffron offers a safe natural nutritional approach to support the brain in combination with daily care and treatments for neurodegenerative disorders.

Saffron’s Potential in Treating Mood Disorders

Mood disorders, including major depressive disorder, have a global lifetime prevalence of up to 20% and can severely impact quality of life5. Research indicates that saffron may play a significant role in enhancing mood and emotional well-being. Its active compounds, including crocin and safranal, are thought to influence neurotransmitter activity in the brain, which can lead to improvements in mood and reductions in feelings of sadness.

Numerous scientific studies have investigated the effects of saffron on depressive symptoms. Research suggests that saffron may support mood regulation through the inhibition of the reuptake of monoamines and the improvement in brain-derived neurotrophic factor signaling6. Furthermore, findings of a meta-analysis of clinical studies assessing depression and anxiety outcomes revealed a similar efficacy between saffron and selective serotonin reuptake inhibitors (SSRIs) in in reducing depressive and anxiety symptoms7. These studies propose that saffron may be as effective as traditional antidepressants, with fewer side effects.

When comparing saffron to conventional antidepressants, the former presents a unique advantage. While conventional medications often come with a range of side effects, saffron natural origins and well-tolerated profile make it an appealing option. Furthermore, its potential for enhancing overall emotional well-being without the adverse effects commonly associated with pharmacological treatments positions saffron as a viable consideration for individuals struggling with mood disorders.

Saffron For Age-Related Macular Degeneration

As we age, maintaining eye health becomes increasingly important, especially in the context of age-related macular degeneration (ARMD). ARMD is a progressive eye condition that primarily affects the macula, the central part of the retina responsible for sharp, detailed vision. It affects approximately 196 million people globally and is the leading cause of severe vision impairment in older adults8. Rich in carotenoids, particularly crocin and zeaxanthin, saffron helps protect the retina from oxidative stress and may enhance visual function. These compounds are known to filter harmful blue light and promote overall eye wellness9.

The mechanisms behind saffron’s protective effects on vision are multifaceted. Crocin has been shown to exert anti-inflammatory and antioxidant properties, which help reduce retinal damage and improve visual acuity10. By inhibiting the expression of pro-inflammatory cytokines and promoting the survival of retinal cells, saffron may effectively slow down the progression of vision loss associated with aging11. Additionally, its ability to improve blood flow to the eyes further supports optimal eye health, making saffron an excellent natural option for maintaining and improving vision as we age12.

Safety and Dosage Recommendations

While saffron is considered safe for most people, some may experience mild side effects, such as digestive issues, headaches, or allergic reactions. Individuals with known allergies to saffron or related plants should avoid its use. Additionally, pregnant or breastfeeding women should exercise caution and consult a healthcare provider before incorporating saffron into their regimen, as high doses may pose risks. Always consult with a healthcare professional before stopping medications and/or to determine the best dosage tailored to your specific needs and health conditions.

The recommended daily saffron dosage typically ranges from 30 mg to 200 mg, depending on individual needs and specific health goals. It is advisable to start with a lower dosage to assess tolerance before gradually increasing. Always consult with a healthcare professional to determine the best dosage tailored to your specific needs and health conditions.

If you or someone you know is experiencing suicidal thoughts or a crisis, please reach out immediately to the Suicide and Crisis Lifeline at 988.

Taylor Woosley studied biology at Purdue University before becoming a 2016 graduate of Columbia College Chicago with a major in Writing. She currently resides in Glen Ellyn, IL.

References:

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