BPA Exposure Is Associated with A Lower Rate of Overall Cardiovascular Health

by | Nov 19, 2024 | 2024, Cardiovascular Health, Environmental Health, Recent Articles

Written by Chrystal Moulton, Science Writer. Sensitivity analysis confirmed that higher BPA exposure is associated with lower odds of optimal cardiovascular health.

cardiovascular health - sliderBisphenol A or BPA is a synthetic organic compound commonly found in medical devices, containers and even food1. The structure of Bisphenol A (BPA) causes the promotion of inflammation, disruption of hormonal signaling, increased oxidative stress, damage to DNA, and leads to cellular dysfunction2,3. With regards to cardiovascular health, research is conflicting. Some studies show significant association between BPA, cardiovascular disease, and cardiovascular disease mortality4-6, while others do not7-9. In the current trial, researchers used data from the national health and nutrition examination surveys (NHANES) to assess whether BPA exposure is associated with lower cardiovascular health10.

Researchers used data from the NHANES cycles between 2005 and 2016. During these cycles, urinary BPA measurements and Life’s Essential 8 assessment [an updated assessment of cardiovascular health] were conducted. Urinary BPA measurements were characterized into tertiles for logistical regression analysis with cardiovascular health. The Life’s Essential 8 metric and diet quality assessed using the Healthy Eating Index- 2015 were also used in assessing the relationship between cardiovascular health and BPA exposure. Socio-demographic information, medical history, and lifestyle activities were collected at baseline. Anthropometric measurements, HbA1C, fasting blood glucose and blood lipids were also taken at baseline. Participants reported medicinal use, diabetes status, smoking, physical activity and sleep patterns at baseline. Multivariable logistical regression analysis was used to explore any relationship between cardiovascular health and urinary BPA levels after adjusting for confounding factors.

Out of 68,466 participants in the NHANES, data from 6635 participants was eligible for this analysis. The average age was 47.59 years old with a nearly 50% distribution of male and female. Of the 6635 participants, 1300 participants had optimal cardiovascular health based on Life’s Essential 8 metric. Individuals in the optimal health category were mostly non-Hispanic white younger females with a higher educational level and income, who were either married or living with a partner. These individuals tended to have lower BPA exposure. Overall, higher urinary BPA levels was associated with a prevalence of lower cardiovascular health scores based on Life’s Essential 8. Researchers found that even after adjusting for confounding factors, participants with higher urinary BPA Levels had a 27% lower chance of achieving optimal Life’s Essential 8 scores (OR = 0.73, P = 0.006). Similar odds were observed for health factors with individuals with higher urinary BPA levels who had a 23% lower chance of achieving optimal health factors on the Life’s Essential 8 assessment (OR = 0.77, P = 0.015). No significant interactions were observed for ethnicity, age, or sex. Additional sensitivity analysis confirmed that higher BPA exposure is associated with lower odds of optimal cardiovascular health.

Results from this analysis demonstrated an inverse relationship between the prevalence of optimal cardiovascular health, based on the Life’s Essential 8 metric, and urinary BPA levels. Further studies will be needed to elucidate any additional associations between gender, ethnicity, and age in relation to cardiovascular health and BPA exposure.

Source: Chen, Yemei, Chao Xu, Ying Huang, Zhaoyan Liu, Jiupeng Zou, and Huilian Zhu. “The Adverse Impact of Bisphenol A Exposure on Optimal Cardiovascular Health as Measured by Life’s Essential 8 in US Adults: Evidence from NHANES 2005 to 2016.” Nutrients 16, no. 19 (2024): 3253.

© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Posted November 18, 2024.

Chrystal Moulton BA, PMP, is a 2008 graduate of the University of Illinois at Chicago. She graduated with a bachelor’s in psychology with a focus on premedical studies and is a licensed project manager. She currently resides in Indianapolis, IN.

References:

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