Higher Serum Levels of Pyridoxal-5’-Phosphate Associated with Reduced Risk of Colorectal Cancer

Written by Taylor Woosley, Staff Writer. Results of the large-scale case-control study show that the sum of PL and PLP were significantly associated with the risk of CRC. Comparing the highest with the lowest quartile, the adjusted ORs (95% CI) were 0.26 (0.20-0.33, Ptrend < 0.001) for serum PLP and 0.51 (0.40-0.66, Ptrend < 0.001) for PL plus PLP.  (more…)

Sufficient Vitamin B6 Levels Associated with Higher Levels of PUFAs in Older Adults

Written by Taylor Woosley, Staff Writer. Analyzing data from the NHANES 2003-2004 shows that US older adults with higher PLP levels was associated with a greater level of EPA, DHA, EPA + DHA, EPA/AA, and (EPA + DHA)/AA. The odds of having high plasma EPA (aOR: 2.03, P=0.049) and EPA/AA (aOR: 3.83, P<0.001) were greater in those with adequate B6 status compared to those with low B6 levels. (more…)

Aged Garlic Extract Supplementation, B Vitamins, Folic Acid, and L-arginine Reduce Cardiovascular Disease

Written by James C. Morton Jr., Staff Writer. In a randomized double-blind, placebo-controlled, clinical research study, aged garlic extract, Vitamin B12, B6, Folic Acid, and L-arginine supplements significantly decreased atherosclerosis progression (7%) and cardiovascular disease factors (9 to 15.5%) compared to placebo group.   (more…)