Specific Differences in Gut Microbiomes Observed in Subjects with Preclinical Alzheimer’s Disease

Written by Taylor Woosley, Staff Writer. Results of this cross-sectional observational study using data from 164 subjects in the ADRC shows that preclinical AD status was most strongly associated with microbial pathways involved in arginine and ornithine degradation (P < 0.001), while the pathways most associated with healthy status was glutamate degradation (P < 0.001).  (more…)

Selenium Supplementation Improves Glutathione Peroxidase Activity in Alzheimer’s Patients

Written by Taylor Woosley, Staff Writer. Analysis of a systemic review of 11 studies and a meta-analysis including 6 papers show that selenium supplementation increased MDA levels significantly by an average of 0.95 (0.44, 1.45) times (p = 0.0002). Furthermore, Se only supplementation significantly increased GPX activity by an average of 0.95 (0.59, 1.31) times (p = 0.00001).  (more…)

HDL-C & Glucose Levels Measured in Early to Mid-Adulthood Associated with Alzheimer Occurrence Decades Later

Written by Taylor Woosley, Staff Writer. Study findings show that elevated glucose levels (15 mg/dL increase) in middle adulthood was associated with a 14.5% increased risk of AD while increased high density lipoprotein cholesterol (15 mg/dL increase) was associated with a 15.4% decreased risk of AD in early adulthood and a 17.9% decreased risk in middle adulthood.  (more…)

Chi3l1/YKL-40 Controls Astrocyte Circadian Clock and Alzheimer’s Disease Progression

Written by Joyce Smith, BS. This study demonstrated YKL-40 is both regulated by clock genes and involved in clearing away the potentially toxic build-up of Alzheimer’s disease (AD) proteins in the brain and that AD patients who carry a genetic variant that reduces YKL-40 levels maintain their cognitive faculties longer than those individuals without the variant. (more…)