By Gene Bruno, MS, MHS – Dean of Academics, Huntington College of Health Sciences. Antimutagenic agents such as Ellagic Acid inhibit the mutagenic process (a process where a cell could develop into a cancer). Posted May 4, 2011.
Ellagic acid (EA) is a phenolic compound with antimutagenic and anticarcinogenic properties. It occurs naturally in some foods such as strawberries, raspberries, grapes, black currants and walnuts. (1) In this formula, EA is standardized at a level of 1% from raspberry extract.
When a cell is exposed to a mutagen and consequently assumes a mutagenic form, it may develop into a cancer. The value of antimutagnic agents such as EA, is that they inhibit the mutagenic process. In one study, the greatest inhibitory effect of EA on a potent mutagen occurred when they were incubated together. (2) In another study, EA demonstrated an almost complete inhibition of the mutagenicity of a cigarette smoke condensate and oral Swedish moist snuff. (3) EA also caused a decrease in the mutagenicity of a food mutagen. (4) In another very interesting study, EA inhibited the activities of certain enzymes in human immunodeficiency virus (HIV) and avian myeloblastosis virus. (5)
- Loarca Pina, G., et al, Mutat Res (1996) 360(1) p 15 21.
- Loarca Pina, G., ibid.
- Romert, L., et al, Mutat Res (1994) 322(2) p 97 110.
- Ayrton, A., et al, Food Chem Toxicol (1992) 30(4) p 289 95.
- Take, Y., et al, J Antibiot (1989) 42(1) p 107 15.