Long-term inhaled dry powder mannitol in cystic fibrosis: an international randomized study.
http://www.ncbi.nlm.nih.gov/pubmed/?term=22198974 Inhaled mannitol draws water out of the cells and into the lung airways as well as reduces entanglements of mucus in the cystic fibrosis patients. This double-blind, randomized, controlled trial of inhaled mannitol, consisted of 192 treated patients (receiving 400 mg twice daily) and 126 control patients (50 mg twice daily) for 26 weeks. There was a change in FEV (forced expiratory volume in 1 sec from baseline in treated versus control groups. The treated group had a 3.75% improvement in FEV(2) versus the control group. There weren’t any adverse events which indicated a potential role for this chronic therapy for cystic fibrosis patients.
Hyperosmolar agents and clearance of mucus in the diseased airway.
http://www.ncbi.nlm.nih.gov/pubmed/16551221 Persistent inflammation in the lungs of cystic fibrosis patients lead to excessive production of mucus, which is difficult to remove by cilia (hair-like structure on surface of airways) or cough interaction. Accumulated mucus in airways leads to airway obstruction, formation of bacterial colonies, recurrent infection and poor quality of life. Hyperosmolar agents have potential to change physical properties of mucus and help clear it by increasing water in the airways lumen. The use of inhaled mannitol (400mg) significantly improved the baseline mucus clearance rate and lung function in cystic fibrosis patients.
Abstracted by Greg Arnold, DC, CSCS, May 17, 2013, from “An updated study of mortality among North American synthetic rubber industry workers” in the December 2005 issue of Occupation and Environmental Medicine. Posted May 21, 2013. Read more »
Abstracted by Jessica Patella, ND on April 17, 2013 from “Effects of a foot bath containing green tea polyphenols on interdigital tinea pedis” from a 2013 publication of The Foot. Posted May 16, 2013. r/ar W Read more »
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Abstracted by Greg Arnold, DC, CSCS, May 10, 2013, from “Beneficial immunostimulatory effect of short-term Chlorella supplementation: enhancement of Natural Killer cell activity and early inflammatory response (Randomized, double-blinded, placebo-controlled trial)” in the July 31, 2012 issue of Nutrition Journal. Posted May14, 2013. Read more »
Abstracted by Greg Arnold, DC, CSCS, November 16, 2012, from “Randomized Clinical Trial of 3 Types of Physical Exercise for Patients With Parkinson Disease” in the November 2012 issue of the Archives of Neurology. Posted May 13, 2013. Read more »
Abstracted by Greg Arnold, DC, CSCS, May 7, 2013, from “Lower vitamin E serum levels are associated with osteoporosis in early postmenopausal women: a cross-sectional study” in the March 28, 2013 issue of the Journal of Bone and Mineral Metabolism. Posted May 13, 2013. r/ar Read more »
Abstracted by Greg Arnold, DC, CSCS, March 31, 2013, from “Weighing the Potential Harms of Computed Tomography: Patient Survey” in the April 2013 issue of JAMA Internal Medicine. Posted May 13, 2013. Read more »