Specific Differences in Gut Microbiomes Observed in Subjects with Preclinical Alzheimer’s Disease

Written by Taylor Woosley, Staff Writer. Results of this cross-sectional observational study using data from 164 subjects in the ADRC shows that preclinical AD status was most strongly associated with microbial pathways involved in arginine and ornithine degradation (P < 0.001), while the pathways most associated with healthy status was glutamate degradation (P < 0.001).  (more…)

Daily Supplementation of Folic Acid, B Vitamins, Vitamin D, and CoQ10 May Be a Potential Preventative Measure of Cognitive Impairment

Written by Taylor Woosley, Staff Writer. Results show that daily vitamin D, B vitamins, folic acid, and CoQ10 supplementation may prevent the occurrence of cognitive impairment in older adults.  (more…)

Selenium Supplementation Improves Glutathione Peroxidase Activity in Alzheimer’s Patients

Written by Taylor Woosley, Staff Writer. Analysis of a systemic review of 11 studies and a meta-analysis including 6 papers show that selenium supplementation increased MDA levels significantly by an average of 0.95 (0.44, 1.45) times (p = 0.0002). Furthermore, Se only supplementation significantly increased GPX activity by an average of 0.95 (0.59, 1.31) times (p = 0.00001).  (more…)

Higher Serum Lutein and Zeaxanthin Levels Associated with a Lower Risk of All-Cause Dementia

Written by Taylor Woosley, Staff Writer. Study findings using data from the NHANES III Survey (1988-1994) show that serum lutein+zeaxanthin was associated with a reduced risk of all-cause dementia, with an inverse relationship being noted between serum β-cryptoxanthin and all-cause dementia.   (more…)

HDL-C & Glucose Levels Measured in Early to Mid-Adulthood Associated with Alzheimer Occurrence Decades Later

Written by Taylor Woosley, Staff Writer. Study findings show that elevated glucose levels (15 mg/dL increase) in middle adulthood was associated with a 14.5% increased risk of AD while increased high density lipoprotein cholesterol (15 mg/dL increase) was associated with a 15.4% decreased risk of AD in early adulthood and a 17.9% decreased risk in middle adulthood.  (more…)

Chi3l1/YKL-40 Controls Astrocyte Circadian Clock and Alzheimer’s Disease Progression

Written by Joyce Smith, BS. This study demonstrated YKL-40 is both regulated by clock genes and involved in clearing away the potentially toxic build-up of Alzheimer’s disease (AD) proteins in the brain and that AD patients who carry a genetic variant that reduces YKL-40 levels maintain their cognitive faculties longer than those individuals without the variant. (more…)