The Association Between Vitamin C Levels and Mortality Due to Alzheimer’s Disease
Written by Harold Oster, MD. Results suggest an inverse association between vitamin C levels and mortality due to Alzheimer’s Disease. (more…)
Specific Differences in Gut Microbiomes Observed in Subjects with Preclinical Alzheimer’s Disease
Written by Taylor Woosley, Staff Writer. Results of this cross-sectional observational study using data from 164 subjects in the ADRC shows that preclinical AD status was most strongly associated with microbial pathways involved in arginine and ornithine degradation (P < 0.001), while the pathways most associated with healthy status was glutamate degradation (P < 0.001). (more…)
Daily Supplementation of Folic Acid, B Vitamins, Vitamin D, and CoQ10 May Be a Potential Preventative Measure of Cognitive Impairment
Written by Taylor Woosley, Staff Writer. Results show that daily vitamin D, B vitamins, folic acid, and CoQ10 supplementation may prevent the occurrence of cognitive impairment in older adults. (more…)
Fenugreek Seed Extract Improves Memory Status and Oxidative Stress-Related Parameters in Older Subjects
Written by Taylor Woosley, Staff Writer. 4-month supplementation of fenugreek seed extract (equivalent to 500 mg of dry extract) significantly lowered the clinical dementia rating score compared to placebo (p < 0.001). (more…)
Selenium Supplementation Improves Glutathione Peroxidase Activity in Alzheimer’s Patients
Written by Taylor Woosley, Staff Writer. Analysis of a systemic review of 11 studies and a meta-analysis including 6 papers show that selenium supplementation increased MDA levels significantly by an average of 0.95 (0.44, 1.45) times (p = 0.0002). Furthermore, Se only supplementation significantly increased GPX activity by an average of 0.95 (0.59, 1.31) times (p = 0.00001). (more…)
Higher DHA Levels Associated with Slower Decline in Alzheimer’s Disease
Written by Jessica Patella, ND. Study observations show an association between higher omega-3s, DHA and EPA and slower cognitive decline in patients with Alzheimer’s disease on acetylcholinesterase inhibitors. (more…)
Higher Serum Lutein and Zeaxanthin Levels Associated with a Lower Risk of All-Cause Dementia
Written by Taylor Woosley, Staff Writer. Study findings using data from the NHANES III Survey (1988-1994) show that serum lutein+zeaxanthin was associated with a reduced risk of all-cause dementia, with an inverse relationship being noted between serum β-cryptoxanthin and all-cause dementia. (more…)
Blueberry Consumption Improves Cognitive Executive Control in Insulin-Resistant Adults
Written by Taylor Woosley, Staff Writer. 12-week supplementation with blueberry powder (equivalent to 0.5 c of blueberries) resulted in significant improvement in lexical access and a reduction of recall intrusion errors, with a significant decline in fasting insulin noted at the 12-week mark. (more…)
HDL-C & Glucose Levels Measured in Early to Mid-Adulthood Associated with Alzheimer Occurrence Decades Later
Written by Taylor Woosley, Staff Writer. Study findings show that elevated glucose levels (15 mg/dL increase) in middle adulthood was associated with a 14.5% increased risk of AD while increased high density lipoprotein cholesterol (15 mg/dL increase) was associated with a 15.4% decreased risk of AD in early adulthood and a 17.9% decreased risk in middle adulthood. (more…)
B Vitamin Supplementation Improves Overall Cognitive Functioning in Non-Aspirin Users
Written by Taylor Woosley, Staff Writer. Findings suggest B-vitamin supplementation provides superior neuroprotective properties, particularly in its ability to reduce the rate of whole brain atrophy, in non-aspirin users compared to participants taking B-vitamins and aspirin. (more…)
Dietary and Supplemental Vitamin D may Support Cognitive Performance in Older Adults
Written by Taylor Woosley, Staff Writer. This study suggests that higher levels of dietary vitamin D intake, serum total 25(OH)D, and 25(OH)D3 resulted in improved cognitive performance in subjects aged 60 years and older. (more…)
Chi3l1/YKL-40 Controls Astrocyte Circadian Clock and Alzheimer’s Disease Progression
Written by Joyce Smith, BS. This study demonstrated YKL-40 is both regulated by clock genes and involved in clearing away the potentially toxic build-up of Alzheimer’s disease (AD) proteins in the brain and that AD patients who carry a genetic variant that reduces YKL-40 levels maintain their cognitive faculties longer than those individuals without the variant. (more…)
Is Obstructive Sleep Apnea Severity Associated with Amyloid Beta Plaque in Brain Hippocampus?
Written by Joyce Smith, BS. Study finds that amyloid beta (Aß) plaques in the hippocampus and brainstem of people with obstructive sleep apnea (OSA) does not correlate with OSA severity. (more…)
Vitamin D Supplementation Protects Against Dementia Risk
Written by Joyce Smith, BS. This study suggests that in a multiethnic cohort of older adults higher vitamin D intake was associated with decreased risk of dementia. (more…)
Clinical and Bacterial Markers of Periodontitis are Associated with Alzheimer’s Disease
Written by Joyce Smith, BS. This large retrospective study examines the association between periodontal pathogens and the incidence of Alzheimer’s disease (AD), AD mortality, and incident all-cause dementia. (more…)
Obstructive Sleep Apnea Is Associated with Higher Brain Amyloid
Written by Joyce Smith, BS. Severe obstructive sleep apnea was associated with an increase in brain amyloid beta (Aß) protein and a greater risk of developing dementia. (more…)
Lithium NP03 Treatment for Late-Stage Amyloidosis in Rat Model of Alzheimer’s Disease
Written by Angeline A. De Leon, Staff Writer. This study demonstrates how microdose NP03 lithium reduced markers of neuroinflammation and cellular oxidative stress during the post-plaque stage of amyloid pathology in a transgenic rat model of Alzheimer’s disease. (more…)
Migraine Headaches Significantly Associated with Dementia in Women
Written by Joyce Smith, BS. In a United Kingdom study, migraine diagnoses were positively associated with all-cause dementia and Alzheimer’s disease in the elderly population, but differed substantially between men and women. (more…)
Sleep Quality as a Biomarker and Predictor of Alzheimer’s Disease
Written by Joyce Smith, BS. Reduced slow-wave activity and low sleep efficiency at baseline were both associated with an accelerated rate of cortical beta-amyloid plaque deposition in healthy older adults. (more…)
Migraine Associated with Increased Risk of Dementia in Women
Written by Angeline A. De Leon, Staff Writer. This study suggests that a history of migraines increases the risk of dementia in women, particularly in women who are sixty years of age or older.
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